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Neither protocol has been validated in a controlled human trial

Discovery of a cyclic cell-penetrating peptide with improved endosomal escape and cytosolic delivery efficiency

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ROS are also produced in the Haber-Weiss reaction (O 2 - + H 2 O 2 OH - + OH - + O 2 ) and the Fenton reaction (H 2 O 2 + Fe 2+ Fe 3+ + OH - + OH - ) with the participation of pro-oxidant ions of transition metals (mostly Fe 2+ /Cu 2+ ) (51)

Huang Z, Pinto JT, Deng H, Richie Jr JP